Biomedical applications of electrospinning: drug delivery

Electrospinning technique offers numerous possibilities in drug delivery applications, by controlling the material (organic, inorganic, biodegradable or non-biodegradable…), the delivered drug or the loading method. In this article, we present an overview of the drug delivery applications of electrospinning.

Fiber materials: Biodegradable and non-biodegradable materials behave differently regarding drug release. Non-biodegradable materials release drug mainly by diffusion. This allows a more precise control of the delivery rate than the non-biodegradable materials, whose degradation increases complexity and may cause very high local drug concentrations. Biodegradable materials have, nonetheless, obvious advantages, like the self-degrading properties and avoiding of further surgeries to remove the scaffold. Most common biodegradable materials include proteins, peptides and blends. A good summary of these compounds can be found in [1].

Electrospun matrices have been used to control the release of many drugs such as antibiotics [2], anticancer drugs [3], proteins [4] or DNA [5]. It has been described the use of electrospinning fibers for drug release in post operatory recovery from abdominal surgery. Antibiotics controlled release helped to avoid abdominal adhesion [6].

An important parameter on drug release is the loading method. The last generation electrospinning devices, like the ND-ES Lab Electrospinning Unit, are able to produce embedded and encapsulated fibers. This is a great advance in drug release control, as the drug can be encapsulated into another polymer. Coaxial, triaxial and multiaxial spinnerets are used to produce embedded fibers, the interior ones carrying the drug.

 

[1] Dhan B. Khadka, Donald T. Haynie, Protein- and peptide-based electrospun nanofibers in medical biomaterials, Nanomedicine: Nanotechnology, Biology and Medicine, Volume 8, Issue 8, 2012, Pages 1242-1262, ISSN 1549-9634

[2] Bolgen N, Vargel I, Korkusuz P, Menceloglu YZ, Piskin E. In vivo performance of antibiotic embedded electrospun PCL membranes for prevention of abdominal adhesions. J Biomed Mater Res B Appl Biomater 2007 May;81(2):530e43

[3] Xu X, Chen X, Xu X, Lu T, Wang X, Yang L, et al. BCNU-loaded PEGPLLA ultrafine fibers and their in vitro antitumor activity against Glioma C6 cells. J Control Release 2006 Sep 12;114(3):307e16.

[4] Zhang YZ, Venugopal J, Huang ZM, Lim CT, Ramakrishna S. Characterization of the surface biocompatibility of the electrospun PCL-collagen nanofibers using fibroblasts. Biomacromolecules 2005 Sep-Oct;6(5):2583e9.

[5] Liang D, Luu YK, Kim K, Hsiao BS, Hadjiargyrou M, Chu B. In vitro non-viral gene delivery with nanofibrous scaffolds. Nucleic Acids Res 2005;33(19):e170.

[6] Bolgen N, Vargel I, Korkusuz P, Menceloglu YZ, Piskin E. In vivo performance of antibiotic embedded electrospun PCL membranes for prevention of abdominal adhesions. J Biomed Mater Res B Appl Biomater 2007 May;81(2):530e43.

© Nadetech Innovations 2017

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